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Appendix A
Understanding Transition Elements as Bose-Einstein Condensates
Einstein predicted in 1924 a, (not yet discovered in 1924), form of matter
during an effort to apply the statistics that worked for the quanta to gas molecules. He predicted what is now
known as the Bose-Einstein condensation state. Einstein stated this in the form of a theorem in the second of two
papers on the subject:
According to the equation of state of an ideal gas developed here at every temperature there is a maximum
density of the molecules that find themselves in motion. On exceeding this density the excess molecules drop out as
'stationary' molecules ("condensed, without attractive forces"). It's noteworthiness lies in the fact that the
"saturated ideal gas" represents not only the state of maximum density of moving molecules, but also the density at
which the gas is in thermodynamic equilibrium with the "condensed matter." A analog of "supersaturated vapor" does
not exist for ideal gases.
What this infers is that if the density were sufficiently large at any
temperature, the quantum gas would form two phases:
- A number of moving molecules providing the pressure of the
gas.
- A number of remaining molecules at rest in a condensed phase, a
condensate.
Einstein also speculated that his theory might apply to electrons in
metals. He proposed that the electrons were effectively a saturated ideal quantum gas and that most of the
electrons were in the condensate form. There are a couple of details of the properties of the electrons of
metals:
- They account for the electrical and thermal conductivity but not the
specific heat
- Specific heat was accounted for by the vibration of the atoms composing
the lattice (Du Long-Petit Law)
- This condition would make a prediction hat the internal temperature of
metal atoms due to the stationary nature of the inner particles would be very low if not at absolute
zero.
The condensed electrons as a stationary quantum gas, would not contribute
to the specific heat. The small number of remaining uncondensed electrons would provide the electrical and thermal
conductivity. Since the electrons of metals obey the Pauli Exclusion Principle:
The state of an electron is specified by its four quantum numbers and constitutes a cell. The population of
this cell can be either zero or unity…
[in a phase-space cell of phase volume h3 . ( De Broglie)]
condensed electrons, (quantum gas) at the thermodynamic equilibrium (unity)
have wave conductive properties as predicted in Quantum Wave theory.
At the end of the 1980's these predictions were proven to be an accurate
picture of electrons in metals when David Hudson's assays showed that these transition elements in this quantum
state are 7000 times more abundant than their metallic forms.
Einstein's prediction, that a condensation of electrons might exist in
metals, indicated that metals, by their transitional nature of incomplete shells of nucleons and electrons, have a
variable stability which can be excited into a state of imbalance from which a new equilibrium might
arise.
We suspect that this increased excitation causes an enhanced coulomb wave to
be generated which attracts other similar atoms in the excited state to connect with the quantum electrostatic
waves that they are emitting. This wave property has been observed in the resonant connectability of iridium atoms.
Iridium forms normal electron bonds at 1.8 angstrom units. In an article in Physical Review, Vol. 62, No.10, Mar.
6,1989, "1776 vaporization's of Iridium atoms onto a supercooled Tungsten plate" Atomic spacing was measured
at 6.3 angstrom units in long chains in two dimensions. In Physical Review, Vol.62, No. 9, Feb. 1989, the
description of the two dimensional nature of cooper paired electrons (bosons, named after N. S. Bose), "Bound
State Cooper Pairing in two dimensions" is expanded on and describes the process that the two dimensional chain
bonding, seen in iridium, exhibited.
For this wave to be sufficiently powerful the electrostatic forces have to
increase from the ground state nucleus energy, (with partially condensed electrons and the uncondensed electrons
from unfinished shells), to a deformed nuclei atom (with suppressed strong binding forces with all electrons
condensed) as in a vaporization state. This is described in the two articles cited above.
Possible configuration scenario-A
1 Upon excitation and increased separation of the incomplete outer
shell nucleons around the completed shells of a nucleus in a transition element, there is a subsequent cascade
effect toward positive screening field increase as the strong binding force is over ridden by the electromagnetic
forces, cooper pairing and super deformation with associated accelerated spin of the expanded nucleus. The odd
number proton transition element BEC's may exhibit at least one basic sublevel after
BEC, before stabilization of the unpaired valence electron. This is an unbalanced state that may flip from BEC back
to metal bonds easily.

This forms an unfinished lower energy m-
element, with one electron, as a positron, looking for a partner to cooper pair with creating a Valence
Funnel.
2 Once another m-element in the same
energy sub level is attracted by the electrostatic force, the valence funnels collapse upon nuclei merging causing
positron harmonization and finalized cooper pairing, thus forming a stable higher energy level
configuration.
Chemical bonding is not available in this energy state, only a suspected
quantum coupling employing the Coulomb wave is available for connecting BEC's. However, in the odd numbered proton
transition elements, this may form atomic quantal materials with unusually high mass values as doubled nuclei, with
drastic fluctuations of gravitational weight and can be made to loose all their gravitational attraction or
increase their weight by heating or cooling.

When these unpaired electrons cooper pair, we suspect that the nuclei conjoin
into a single nuclear mass which now resonates near the zero point frequency. The amplified electrostatic forces
may be driven by a suspected collapse of the bosons (paired electrons) into a ring shape after condensation and
brought about by the increased positive screening forces. As this condensed ring is set into rotation by the
spinning nucleus, the electrostatic forces generate a coulomb wave flowing out along the plane of rotation. The
former unpaired electron fermions are now balanced into bosons and superconduction begins along with the associated
Meissner effect.
Possible configuration scenario-B
As in the above description, the process of energy state change that causes
cooper pairing might follow much of the Scenario-A description. The bosons may not form a disc but rather a tightly
wound area, drawn in close to the spinning double nucleus by electrostatic forces. Field related phenomena and, in
particular bosons formed from Cooper paired electrons are without charge and unaffected by charged particles.
However, the spinning frictional force potential of the SD nucleus might draw the boson region (no longer really
acting like a cloud of electrons), into a nested region close to the Nucleus. In partially condensed Atoms with a
spinning nucleus and a still unpaired electron, the orphaned particle would be drawn in close to the nucleus as the
only negatively charged particle. It may stay active as a special case valence electron or fall into the nucleus
and be destroyed by the overwhelming positive charge.
PROCESS OF EXCITATION.
It is shown that the two nuclear forces, strong and
electromagnetic, have inverse relationships. As we know, a proton is constructed by
three quarks and a gluon. It is felt that the gluon is the carrier of the strong binding force. As the nucleons
begin to increase separation by whatever means, the strong binding force decreases in influence as the gluons of
the protons are spaced farther apart, and the electromagnetic forces increase as well as the relative positive
charge of the atom. Transition elements have unfinished harmonic shells in the nucleus, not just the outer electron
shells. The unfinished electron orbitals are expressions of incomplete harmonic shells of the nucleus. The result
of this is an unbalanced mass in rotation and is the means of exploitation to excite the nucleus to spin and deform
its shape, thereby increasing the spacing between the nucleons and increasing the positive screening
potential.

It has also been observed that atoms can be aligned by magnetic resonance and
that magnetic force can start the rotation of an out of round charged mass as can the addition of heat to force
more molecular glancing collisions to start the spin process.
Initiating rotational forces also initiates flow and field phenomena thus
increasing the electromagnetic forces around the axis of rotation like a flow of electrons in a wire, or the
electromagnetosphere generated by the spinning core of the Earth. Things happen very quickly once the process of
rotation starts with exponential changes in forces.

Hypothesized Strong force and Electromagnetic force changes during Bose-Einstein
Condensation
Once the nucleus in a transition element with sufficient pre-existing
condensed electrons, is forced to rotate on its axis, centripetal forces starts the nucleon separation process of
decreasing strong binding force while increasing electromagnetic positive force. As the increasing positive
screening potential expands out, due to the relative enlargement of the nucleus by spin deformation and increased
separation of the protons, the harmonization of the remaining uncondensed electrons takes place taking the atom to
a superconductive state of high spin and giving it the ability to quantum connect employing the coulomb wave
generated by the increased rotation rate forces (see above Physics Review mar., 6, '89).
Physical Review 6, Vol. 41, No. 4, Apr, 90, article entitled, "Quantum
size effects in rapidly rotating nuclei" indicates that Cooper instability causes super deformation (2 to 1
spin axis ratio) during quantal state changes in transition elements.
It is important to note in the original theorem by Einstein that The Quantum
Gas condensates are "without attractive forces". This important observation gives these elements unusual
theoretical properties, not the least of which is a completely positive charge by virtue of having no unpaired
electrons and an expanded nucleus surrounded by quantum wave conducting bosons. A whole integer integral spin
energy particle relationships that is indicative of field generated phenomena and the coherency of photons (also
bosons) seen in laser light.
It has been predicted by the Sakarov theory of gravity, Puthoff's
mathematical proof of Sakarovs theory and physically shown by Hudson and others that these materials loose
4/9th of their gravitational weight after Cooper pairing and nuclei deformation. It should be noted that
this 4/9 number is affected greatly by conditions and is used as an example that is not proven in all situations A
possible explanation is a anti gravity, or (better still) a repulsive gravitational force, is exhibited expressed
perpendicular to the plane of rotation as a result of the compressed gravitational forces directed toward the axis
of spin by the disc of Cooper paired electrons. This force may prove to be the explanation behind the Meissner
effect, which increases in energy by induced magnetic fields, which are absorbed, and coincidental with higher spin
rates and quantal flow rates.
It is suspected that Meissner field effects may be inertial field boundary
characteristics produced by the rotationally compressed gravitational frequency tapping the vacuum energy at 4.2 x
10-42 wavelength.
Dimensional / Space-time Sheet Theory
This topic is made possible by the Cooper pairing of a quantum gas (screened
electrons) as an identical but opposite wave cancellation phenomena.
Typically when two identical but opposite phase electromagnetic waves cancel
each other, the residuum vibration, the Planckian constant, 'k', is the result. This frequency, 4.2 x
10-42 wavelength is the resultant residuum vibration of all frequencies after cancellation
as it is the result of the process, not the wavelength frequencies of the cancellation action .
In a sense, this is the 'after image of light'
The Dirac-Boyer model of the vacuum energy as the spectral density of the
cancellation frequency cubed, is uncannily similar to the wave cancellation phenomena described by Planck as a
resultant and latent energy.
When electron condensation takes place by Cooper pairing, the process
involves the positive screening of all the electrons. This set of ½ spin fermions are of two types represented in
combinations of the four components:
- clockwise spin (i.e.;N pole up)
- counterclockwise spin or reversed pole spin (i.e.; S pole
up)
- e+ (positron)
- e-
The condensation of these two field normal/field reversed particles can
only take place if one or the other particle can be made to harmonize with the opposite.
It is suspected that the positive screening field extends to the last filled
electron shell. This would allow the valence bonding required for the metal to have thermodynamic forces and
bonding forces and make transition element atoms partial BEC's even in the ground state metallic forms and
evidenced by the internal temperature of SD atoms as very near absolute Zero thus not contributing to specific heat
because this area of the atom has no specific heat and is stationary thereby acting a non-contributing part of the
atomic system.
It is suspected that the positive screening field converts field reverse spin
electrons into positrons to enable the field forward spin electron to harmonize and Cooper pair with the
reversed-reversed field spin particle. The two ½ spin energy integral electrons can now vibrate in step like
waves, increase in amplitude and combine into a single whole integer integral spin boson with wave
characteristics showing no positive or negative charge as the two have merged from particle state to relationship
state.
It is suspected that once the nucleus is set in rotation, a collapse of the
boson field into a two dimensional disc of bosonic energy takes place or a condensation near the nucleus as a
region of resonance wave energy and may be forced into rotation by the rotating electrostatic energy created by the
spinning nucleus. This event begins an oscillated gravitational / boson field compression toward the axis of the
spinning nucleus. This would have the effect of generating a repulsive gravitational force perpendicular to the
plane of rotation and produce an inertial field effect by the constrained internal forces. Theoretically this would
slow time at the inertial field boundary by deflection toward the compressed gravity vector with this field effect
increasing in potential with rotational speed increases. It would also cause the atom to oscillate as system
potentials of gravitational compression are reached and emitted perpendicular to the plane of rotation as waves at
the oscillation frequency and be manifested as a coulomb electrostatic force that may oppose the nuclear positive
force to allow atoms of identical energy and state to find an equilibrium of these two opposing forces to resonance
connect employing this quantal wave. Additionally it may be this equilibrium process that might allow large
assemblages of matter in this state to act as an ideal gas at room temperatures and resonant connect into a system
generating a Meissner field effect.
It is suspected that this oscillation frequency is 'k', 4.2 x
10-42 wavelength due to the cancellation effect during electron pairing producing the residuum vibration
as a result.
Superheavy or Degenerate Matter
There has been a predicted stability in nuclei at atomic weight 300-400 but
there appears to be no way of creating it in cyclotrons. This predicted matter can, however, theoretically be
produced inside dwarf stars of around one solar mass and above. This is the mass necessary for degenerate pressure
to be reached for collapsing forces to overcome all atomic equilibrium forces and compress nuclei into nuclei.
Although it is suspected that all transition elements form diatomic merged nuclei, we feel that
transition elements that have odd numbered protons, like gold-79 or
Iridium-77 are suspected to have a two phase B-E condensation to stability which would enable two odd numbered
proton elements like Au-79 to screen and cooper pair all but one electron during the phase one condensation.
Hypothetically diatomic forms may be constructed by the two unpaired electrons harmonizing between the two phase
one condensates and they draw the two 79 proton nuclei together to form a double nuclei of 156 protons and a
combined boson disc. The relative atomic weight would have been At. Wt. 394 but when the approximate 4/9 reduction
in gravitational weight after BEC is taken into account, the atom would have a relative weight of 236, very close
to the weight of Uranium, an inner transition element.
Gravitational weight Changes Exhibited in transition Elements during
Quantum Energy State Changes
Much has been made of the decrease in weight these elements exhibit after
BEC. This may be explained by studies involving spinning and stationary masses in a gravity
field.
Michael Faraday 1831
- Invention of the one piece Homopolar Generator exhibiting inertial field
phenomena
Podkletnov, E and R Nieminen, Physica C 203, 1992, pg 441-444 North
Holland "A possibility of gravitational shielding by bulk Yba2Cu307-x
superconductor"
- Gravity is attenuated above a spinning superconductor, and the
attenuation is related to the spin rate and the frequency of the electromagnetic field levitating the
object.
- The shielding force depends on the rotational speed of the disc and has
a tendency to increase with the speed of rotation.
Hudson, 1990's
- m-elements will loose 4/9 of their
gravitational weight after BEC.
- These elements can be made to weigh less than zero.
- Beyond the zero weight point they visually disappear, but are still
measurable as a negative weight.
- When cooled they gain weight.
DePalma, 1970's
- Rotating objects falling in a gravitational field are accelerated at a
rate greater than 'G'.
- Pendula utilizing bob weights which are rotating, swing non sinusoidally
with increased periods.
- Two gyroscopes on the same axle, spinning counter rotationally at 7600
rpm with an additional 4 rps of the support cylinder, weighted 4 - 6 lbs less than its 276 lb starting weight
while operating.
- Rotating objects create an inertial field that distorts (slows)
time.
This phenomena may be a distortion of normally isotropic space, the amount
of distortion being represented by the reflected internally constrained forces explicitly developed by the machine,
or object in rotation. These experiment results are not always along the gravity gradient, indicating discrete
field phenomena. These experiments may exploit time as an aspect of the zero point. In condensed m-elements this weight loss phenomena may be explained by understanding that these elements are
spinning and the former electrons are now rotating in a plane perpendicular to the spin axis. This may give them a
relative vector force like any flow of electrons through a wire as described as the 'left hand rule'. In the left
hand rule, a flow of electrons will generate an electromagnetic field rotating clockwise to the direction of
flow:

flow creates the field
This is remarkably like the rotational field phenomena described by the above
authors, and is similar to the structure of the high spin transition elements as
depicted below

field creates the flow
This act of rotation generated field effect is suspected to create a
gravitational attenuation along the axis of rotation that may produce and expansion of space at one axis pole and a
contraction of space at the opposite pole that mimics a two pole magnetic field. This may be employed in exotic
propulsion systems in the future and allow three dimensional quantum connectivity of the elements in a resonance
connected system of these atoms in this state.
In addition to the gravitational weight changes due to rotating masses, it is
suspected that the transition element BEC atom generates a Meissner field in systems
of resonance connected identical atoms in this state that excludes gravity when
energetic enough, and the effect on the atom caused by Cooper pairing forces the atom to vibrate at, or very near,
the residuum vibration, 'k' when even the valence electrons (now Cooper Paired) are excluded from contributing to
specific heat.
A very curious relationship between metallic state and non-metallic high spin
state may be expressed in the conditions of the electrons and nucleons as an inverse
relationship.
- Ground state atoms have stable nuclei and active
electrons
- high spin atoms have active nuclei and stable (former) electrons as
bosons
When an examination of the electron shells by energy level and the amounts
of electrons found in each is done, the distribution of electrons might be shown to represent a boson toroidal ring
that has been lowered in energy level and expanded out amongst electron orbitals as fermions of various energies.
Transition elements after BEC may, because of their atomic mass, enable them to produce a quantal disc with enough
potential to charge the nucleus with static electric energy thus generating the coulomb wave used in resonance
connectivity and deformation of the nucleus as the 'charging' mechanism of the high spin atoms.
Hypothesized Distribution of electrons per energy
level

Another way to view this is by considering the electrons as being either
expanded or collapsed, and considering their energy levels as particles (fermions) or bosons
(relationships).
- In the particle state the positive screening potential of the nucleus
maintains distancing by demanding ordered pairs of spin forward and spin reverse electrons as they fill the
electron orbitals.
- In the BEC process, ordered electron pairs in the electron shells Cooper
pair as the Positive screening potential expands changing spin reverse electrons, now in a positive field, to
change into positrons, allowing them to harmonize and Cooper pair with the spin forward electrons and a cascade
of higher and higher spin, greater and greater positive field, lower and lower strong binding force and higher
and higher electrostatic forces occurs.
We propose:that the electrostatic forces are being driven by the
friction between the nucleus and the boson quantal field that is vibrating near the Zero Point Energy and taping
the space-time fabric to bring energy into an overunity condition that these m-state elements represent and vacuum
energy is being pumped into the system.
Our feeling is that once the electrons cooper pair, they all achieve a more
or less identical energy state and tend to congregate close to the nucleus with distance regulated by spin rate
inertial field changes. Double nuclei in the odd proton transition element BEC's, and perhaps the even numbered
proton transition elements as paired nuclei, have a bigger nucleus, but perhaps not a greater radius of quantal
field potential by the addition of the second set of Bosons. As massless as photons are, they very well might be
under different constraints than the remaining nucleus particles and no longer follow predicted solid matter
behavior in addition to having no charge.
Other considerations:
It has been observed that a spinning disk can attenuate gravity above the
disk along the gravity gradient.
- The velocity of the radial quantal disk theorized as rotating around the
spinning nucleus may play a part in the generating of the Meissner field, a gravity excluding field, seen in
these superconductors and a possible mechanism in its generation.
- This gravitational attenuation along the spin axis may additionally be
involved in the bonding of the m-element atoms as described
above.
- The tuning of the atom to the Planck constant during cooper pairing
forces the atom to vibrate near the Zero Point Energy, ( E0 = hf x ½, or the spectral
energy density 'p' of the Zero-point fluctuation as a function of that frequency, 'w', such that p(w) =
kw3 )
- These elements may be overunity systems.
It must be remembered that electrons lose energy, but restore the loss by
slipping into the zero point to tap the vacuum energy. BEC's are mostly in the vacuum energy with their converted
electrons as bosons.
Appendix B
Glossary
BEC Although any atomic or subatomic particle can form a Bose-Einstein
condensate, our focus is on transition element Bose-Einstein Condensates. A transition element atom that has
changed energy state to a quantum state of high spin. Cooper pairing of all electrons is forced by increased
positive screening as the nucleus spins and spreads apart the nucleons.
Boson A photonic energy package that is two particles in a harmonic
relationship
Cooper Electron Pairing The harmonization of opposite phase electrons
in reaction to positive screening potential forces from the nucleus to form a high energy relationship
(boson)
Covalent bonds Consisting of a pair of shared electrons between two
atoms, typically found in atoms with high electron affinity like gases
Dipole A molecule that is electrically unsymmetrical, causing it to be
oppositely charged at two points
Electron affinity The characteristic of elements that have nearly
finished outer electron shells to accept an electron easily
Electronegativity The attractive force that an atom of an element has
for shared electrons in a molecule
Hydrate A substance that contains water as part of its crystalline
structure
Hydroxyl One atom of hydrogen and one atom of oxygen. Strong
electrolyte ion used in pH adjustment.
Immiscible fluid Incapable of mixing into solution.
Inter molecular bond Bonds between molecules
Ion An electrically charged atom or group of atoms. A positively
charged ion is a cation (+) that has given up an electron to chemically bond with another atom making it smaller,
and a negatively charged ion is an anion (-) which has accepted an electron from another atom making it
larger.
Ionic bond A chemical bond between positive and negative ions where
there is a transfer of electrons.
Molecule A small, uncharged individual unit of a compound formed by
the union of two or more atoms
Non-metallic transition elements An individual atom of a transition
element or Diatom
Nucleon A general term describing the constituents of an atomic
nucleus of neutrons and protons
pH Insert Mikes description A method of expressing the H+ (hydronium
ion) concentration , or acidity, in a solution. pH = -log [H+]. pH7
is neutral, <pH7 is acid, >pH7 is base.
Polar covalent bond A bond between types of atoms of different
electronegativity causing one to have a more negative charge than the other causing an unequal distribution of
electrical charge
Positive screening potential The nuclear force that prevents electrons
from falling into the nucleus
Valence electron Electrons in the unfinished (unfilled) outer shells
of atoms that are available for chemical bonds
Appendix C
Natural Sources of Transition Elements found in Sea
Salts
The following list of precipitate yields are based on 1 cup of salt dissolved in one gallon
of water or one gallon of sea or ocean water.
Source Brand Yield (ml)
Sun dried sea salt Bulk from health food store 20
Medical lake salt Medical Lake/ Washington 20
Mt. Carmel water Mt. Carmel/ Illinois 50
Ocean water Santa Barbara/ California 200
Ocean water Oregon coastal water 1000-2000
Salt Lake concentrate Great salt Lake/ Utah 3500
Dead Sea water Israel 6500
Dead Sea Salt Dead Sea Products 2220
Dead Sea Salt Masada 1700
Dried Sea Salt Ocean Potion 1200
Celtic sea salt Bulk from health food store 275
Celtic sea salt Brittany Sea Salt 200
Sun dried ocean salt DeSouz's Solar Sea Salt 180
New Zealand sea salt Pacific salt 24
New Zealand sea salt Comvita 30
Mediterranean sea salt La Baleine 10
Utah mined salt Utah 10
Ordinary sea salt Bulk from food co-op trace
Appendix D
Transition Element Rhodium Clusters in Genetic Therapy
R37GM33309 BARTON, JACQUELINE K METAL PROBES AND DRUG BINDING TO DNA
-PROJECT NUMBER........5 R37GN33309-15
INSTITUTIONGN FY 97 BARTON, JACQUELINE K
INITIAL REVIEW GROUP IRGBMT CALIFORNIA INST OF TECHNOLOGY
AWARD AMOUNT............
PASADENA, CA 91125
PERFORMING ORGANIZATION: CALIFORNIA INSTITUTE OF TECHNOLOGY
TITLE: METAL PROBES AND DRUG BINDING TO DNA
FUTURE YEARS 3
ABSTRACT:
The goal of this research program is the design and application of transition metal complexes to
target specific sites on DNA and RNA. Such designs form the basis for novel chemotherapeutics targeted to nucleic
acids with predictable sequence-specificities and high affinities as well as providing new tools for biotechnology.
We have focused on the construction of octahedral complexes of Rhodium (III) containing the
phenanthrenequinone diimine (phi) ligand. These complexes bind duplex DNA primarily through melloinintercalation in
the major groove, with site selectivities being governed by non-covalent interaction of the ancillary ligands with
the nucleic acid. With photoactivation, the complexes promote direct DNA strand ssicission at the site of
intercalation, and this photocleavage serves to mark the site of binding. We intend (i) the construction of a new
metalloinintercalators with predictable site-specificities and affinities, comparable to those of DNA binding
proteins, (ii) the detailed characterization of the structural basis for these site specificities, (iii) the
application of metal complexes to probe RNA and DNA structures, and (iv) their application to examine the
site-specific inhibition of nucleic acid processes. Derivatives of Rh(phen)2phi3+ will be prepared to pose an array
of functional groups on the ancillary ligand matched to donors and acceptors in the DNA groove. Using both
shape-selection and direct readout, derivatives of delta-Rh(phen)2phi3+, functionalized on the periphery will be
prepared to target 6 base pair DNA sites. In exploiting the sequence-dependent flexibilities of DNA, derivatives of
delta-Rh(phen)2phi3+ will be prepared to target 5 '-XTATAX-3' sequences. Tow dimerization stratagies, metal
activated chelation and covalent eimerization through disulfide linkage, will be exploited to expand the length of
sequences targeted (8-10 base pairs). Mixed ligand colplexes containing three different chelating ligands, as the
intercalator, dimerization ligand, and primary recognition ligand, will also be constructed. Binding site
selectivities will be determined on DNA fragments and oligonucleotides based upon photoactivated cleavage. Base
substitutions and sequence-specific unwinding assays will be used to probe specific interactions. Detailed
structural information will be obtained in high resolution NMR experiments of rhodium-oligonucleotide complexes and
using x-ray crystallography on Iridium analogues. In applying metal complexes to probe nucleic acid
structure, the hammerhead and Anabaena RNA ribozomes, HIV TAR RNA, and well-defined DNA mismatches will be
examined. Importantly, with the development of complexes differing in levels of site-specificity, charge and
solubility characteristics, as well as in rates of dissociation, we intend to test the efficacy of metal complexes
in functioning to inhibit nucleic acid processes. Metal complexes will be examined as site-specific inhibitors of
DNA and RNA polymerase. Analogous experiments will then be conducted in bacterial cells, where cellular uptake,
photoactivated DNA cleavage, and site-specific inhibition of RNA synthesis will be assayed. This program, from
design to functional application, represents an almost unique opportunity to develop systematically rational
strategies for site-specific nucleic acid targeting by small molecules.
Appendix E
The Biblical Material Manna, as Non-metallic transition
elements precipitated by atmospheric processes
Manna, as it is known to the Hebrew Religion, is the matter that fell from
heaven during the Exodus. When it was found on the ground the two phrases used to describe it was, 'what is it?'
(Ex. 16.15) , 'Man hu', and 'It is Manna' which might mean, [It is 'what is it'] Much is said in the Book of
the Exodus about the characteristics of Manna and much is known about the mining and smelting operations that the
Egyptian Pharaohs and Mesopotamian Kings kept operating in the Sinai, at that time, for Gold, Silver and Copper
production. These, of course, are Transition Elements. To understand the material that fell from Heaven for the
Hebrew, one has to take into consideration the other factors at play at that time in that place.
The Royal Mines in the western Sinai Peninsula, were staffed by miners which
followed a weekly routine of work and rest. They would dig the ores from excavated sites in the volcanic soils of
the region and fire these ores in ancient furnaces and ovens to melt out the metals. It is possible that a large
amount of volitized Metals as individual atoms was released by this process and were lifted aloft by the furnace
heat of the smelting process and moved it southeast of the mines every day by several hundred miles. On one day a
week, the mines would not fire ores and the furnaces were maintained and cleaned. One day a week, the air was not
charged with the Furnace exhaust gases. This routine matches the biblical reference that Manna did not fall from
the sky on one day per week.
Moses and his tribe left Egypt and headed east into the Sinai. During this
escape, they encountered a large Army on its way to invade Egypt. They chose to avoid them and went southerly into
the Sinai. Their solution to starvation was the discovery of a white frost-like material on the ground in the
morning (Ex. 16.14) which was used to sustain them all for forty years.(Ex. 16.4-35), and was suitable for various
forms of processing (Nm. 11.6-8). It had a metaphorical description, Food from Heaven, (Ex. 16.4), and
Heavenly Grain, (Ps. 78.24 - Ps. 105.40). It was described as an edible substance, white in color, abundant
and fine like frost on the ground, with a sweet, rich, creamy taste, similar in nature to the white coriander herb
seed.
As the exhaust from the smelting operations charged the atmosphere with gases
containing precious metals as individual elements, the thick, salt laden air from the Mediterranean moved northwest
to south east, mixing with and moving the gases down wind towards the Israelites. As the Air-mass cooled into the
night, the particles from the smelting operations started forming rain drops which fell as a light rain before dawn
as the Air-mass over the Sinai reached its lowest temperature and condensed. This precipitation brought the gases
back to Earth as a milky rain. When the sun came up and evaporated the water, the Manna was left as a fine white
powder on the ground. Manna never fell on the Sabbath because the furnaces were shut off the day before for weekly
cleaning on the off day for the miners.
This smelting method is the same method employed by Bezaleel to make the
Bread of the Presence of god for Moses in the book of the Exodus; Moses and Bezaleel at Mt. Sinai. Bezaleel was a
goldsmith. Not only did he make the Bread of the Presence of god, he made the Ark of the covenant. The word
'Covenant' means 'to eat bread with'. Bezaleel burned volcanic ores to extract the white powder of gold. This gold
preparation was identical to the smelting process at the mining sites far up wind from Mount Sinai. Bezaleel had no
use for the metal melted from the ore for the bread of the presence of god, he needed the more important form of
gold. The white powder form when gold is burnt.
It is a good argument that the Manna which fell from the sky for Moses and
the Israelites was the precipitation of mining furnace exhaust, and that Manna was atoms of precious elements in a
changed state. But why did it keep a host wandering the desert fed and healthy for forty years? A clue may be left
as the reference,
"...and gave you Manna to eat...in order to teach you that man does not
live on bread only, but that man may live on anything that the lord decrees" (Dt. 8.3)
Some have theorized that the Tamarisk bush, a shrub that produces a white
gummy material, and is native to the Sinai, is the source of Manna but fail to recognize that this happens
seasonally and not all year long.
Studies of brain tissue that was carbonized, had the transition elements
extracted and converted to metal was analyzed spectroscopically. This study showed that they contain 5% by dry
weight m- element Rhodium and m-element Iridium. These
chemicals are also extracted by heating (to volitization) volcanic soils.
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